Remote eradication of delayed infection on orthopedic implants via magnesium-based total morphosynthesis of biomimetic mineralization strategy

Orthopedic delayed and late infections are devastating afflictions for patients who have undergone implantation. Even though versatile antibacterial modification on medical devices brought the hope of eradicating pathogenic bacteria. The synthesis late-term properties with total morphosynthesis nonetheless remains an elusive goal. Herein, we utilize a mineralized strategy coupled ion exchange to generate lamellar-type magnesium calcium phosphate thin films three-step pathway: Construction nanofiber porous structure substrate as ions reservoir, incorporation substitutional transition sodium titanate layer, mineralization lamellar coating. Synthetic coatings exhibit excellent osteointegration effects in infectious scenarios. More importantly, underlying layer can blow up possible infection like landmine after upper coating is degraded under physiological environment. This work highlights pivotal role mediating growth ensuring possibility eliminate time-dependent degradation.